2-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine → HCID 86615445, 화합물

반응식

I[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1(B(O)O)[CH:25]=[CH:24][CH:23]=[CH:22][NH:21]1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:23]=[CH:22][N:21]=1

참가 물질

반응물 2

HCID 574686822-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine

HCID 68828138HCID 68828138, 화합물

생성물 1

HCID 86615445HCID 86615445, 화합물

실험 절차

The title compound was prepared from 2-iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine (example A.58) (5.45 g, 15 mmol) and commercially available 2-chloropyridine boronic acid (2.48 g, 15.75 mmol) according to the general procedure IVb. Obtained as an off-white solid (3.82 g, 73%). MS (ISP) 349.2 [(M+H)+] and 351 [(M+2+H)+].

출처 및 근거

ORD 기록: ord-8877c8a14c9e4625a42597eaabd20aa3
출처 데이터셋: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07642264B2

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