Tributyltin Chloride → 2-(4-Tributylstannanyl-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

온도

0 °C

To a stirred solution of 2-(4-iodo-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (Example E.68) (0.48 g, 1.0 mmol) in THF (5 mL) was added at 0° C. isopropyl-magnesium chloride lithium chloride (1M in THF, 1.22 mL, 1.22 mmol). The reaction mixture was allowed to stir for 15 min at 0° C., tributyltin chloride (0.43 g, 1.33 mmol) was added, the reaction mixture was stirred at room temperature for 16 h, poured into saturated ammonium chloride solution (30 mL) and extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with brine (30 mL), dried (MgSO4) and evaporated. The crude product was further purified by flash chromatography on silica gel (ethylacetate/heptane) to yield the title compound (0.27 g, 42%) as a light yellow oil. MS (ISP) 649.2 [(M+H)+].

1. customwas added at 0° C.
2. stirringthe reaction mixture was stirred at room temperature for 16 h
3. extractionextracted with ethyl acetate (2×50 mL)
4. washThe combined organic layers were washed with brine (30 mL)
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe crude product was further purified by flash chromatography on silica gel (ethylacetate/heptane)

ORD 기록

ord-8580e0d85c1f4da1bbb2fbd4515924ea

출처 데이터셋

uspto-grants-2010_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07642264B2