(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone → 4-[2-(4,4-Difluoro-piperidine-1-carbonyl)-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

반응식

[F:1][C:2]1([F:29])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:19][CH:20]2[CH2:25][CH2:24][N:23](C(C)C)[CH2:22][CH2:21]2)=[CH:14][CH:13]=3)=[O:9])[CH2:4][CH2:3]1.Cl.[C:31]([O:35][C:36](N1CCC(OC2C=C3C(=CC=2)NC(C(O)=O)=C3)CC1)=[O:37])([CH3:34])([CH3:33])[CH3:32].C1(N2CCC(OC3C=C4C(=CC=3)N(C3C=NC=NC=3)C(C(N3CCC(F)(F)CC3)=O)=C4)CC2)CCC1>>[C:31]([O:35][C:36]([N:23]1[CH2:24][CH2:25][CH:20]([O:19][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[NH:11][C:10]([C:8]([N:5]2[CH2:6][CH2:7][C:2]([F:29])([F:1])[CH2:3][CH2:4]2)=[O:9])=[CH:18]3)[CH2:21][CH2:22]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]