Cyclobutanone → 5-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester

HRID 19897

반응식

HRID 19897 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:22]2[CH:23]=[N:24][CH:25]=[N:26][CH:27]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)=[CH:10][CH:9]=2)=[O:5])[CH3:2].[C:28]1(=O)[CH2:31][CH2:30][CH2:29]1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:22]2[CH:23]=[N:24][CH:25]=[N:26][CH:27]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH:16]1[CH2:21][CH2:20][N:19]([CH:28]3[CH2:31][CH2:30][CH2:29]3)[CH2:18][CH2:17]1)=[CH:10][CH:9]=2)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 14496CyclobutanoneHCID 670179215-(Piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 670179025-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester

실험 절차

In analogy to the procedure described for the synthesis of example 43, step 7, the title compound was synthesized from 5-(piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester (example 44, step 2) and cyclobutanone. The title compound was obtained in 58% yield as light yellow solid. MS (m/e): 421.1 (MH+, 100%).

후처리

  1. customIn analogy to the procedure described for the synthesis of example 43, step 7

출처 및 근거

ORD 기록
ord-de48f38b6fee47caaefe5a4212650c77
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745479B2

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