Hydrazine → 6-(4-Methoxyphenyl)-2,3-dihydropyridazin-3-one
반응식
[NH2:1][NH2:2].O[CH:4]([CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)=O)[C:5](OCC)=[O:6]>C(O)C>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[N:2]=[N:1][C:5]([OH:6])=[CH:4][CH:10]=2)=[CH:14][CH:15]=1참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
4.91 ml (98.0 mmol) of hydrazine was added to an ethanol solution (50 ml) of 20.62 g (82.0 mmol) of the obtained ethyl 2-hydroxy-4-(4-methoxyphenyl)-4-oxo-butyrate, and the reaction liquid was stirred at 60° C. for 4 h ours. The reaction liquid was concentrated under reduced pressure, and the resulting solid was washed with diethyl ether to obtain 16.18 g (yield: 80%) of 6-(4-methoxyphenyl)-pyridazin-3-ol as a white solid.
후처리
- customthe reaction liquid
- customThe reaction liquid
- concentrationwas concentrated under reduced pressure
- washthe resulting solid was washed with diethyl ether
출처 및 근거
- ORD 기록
- ord-8ffe7e6c3eb94d889afc3a3446075601
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07645756B2
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