(3-Ethoxy-5-isobutoxy-phenyl)-methanol → 3-Ethoxy-5-isobutoxy-benzaldehyde

HRID 1990849노트

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HRID 1990849 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:15][OH:16])[CH:7]=[C:8]([O:10][CH2:11][CH:12]([CH3:14])[CH3:13])[CH:9]=1)[CH3:2]>CN(C=O)C.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[C:8]([O:10][CH2:11][CH:12]([CH3:13])[CH3:14])[CH:9]=1)[CH:15]=[O:16])[CH3:2]

참가 물질

4

반응물 1

HCID 68694893(3-Ethoxy-5-isobutoxy-phenyl)-methanol

생성물 1

HCID 587063263-Ethoxy-5-isobutoxy-benzaldehyde수율 100.8%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

To a solution of (3-ethoxy-5-isobutoxy-phenyl)-methanol (0.28 g, 1.25 mmol, 1.0 equiv) in DMF (20 mL) was added activated MnO2 (1.09 g, 12.48 mmol, 10.0 equiv). The reaction mixture was heated to 60° C. for 2 h, filtered through Hyflo Super Cel and concentrated by evaporation under reduced pressure yielding 0.28 g (99% yield) of the title compound. MS (ISP): 223.0 [M+H]+.

후처리

  1. filtrationfiltered through Hyflo Super Cel
  2. concentrationconcentrated by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-b4013a8a1e584b3f9476883d7a452734
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07645753B2

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