HCID 68510790, 화합물 → HCID 59128269, 화합물
반응식
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:5]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[CH3:2]>ClCCl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH:10]=[O:11])[CH:7]=[CH:6][C:5]=1[C:12]1[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=1)[CH3:2]참가 물질
4
실험 절차
To a solution of (2-ethoxy-4′-fluoro-biphenyl-4-yl)-methanol (0.42 g, 1.71 mmol, 1.0 equiv) in dichloromethane (20 mL) was added activated MnO2 (2.97 g, 34.11 mmol, 20.0 equiv). The reaction mixture was stirred vigorously for 3 h at ambient temperature and then filtered through Hyflo Super Cel. The organic phase was concentrated by evaporation under reduced pressure and the crude reaction product purified with column chromatography on silica eluting with hexane/ethyl acetate (4:1) providing 0.33 g (79%) of the title compound. MS (EI): 244.1 [M]+.