Acetyl chloride → N-(2-Bromo-5-chloro-4-methoxyphenyl)acetamide

HRID 1991089노트

반응식

HRID 1991089 반응식
[Br:1][C:2]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([Cl:11])=[CH:5][C:3]=1[NH2:4].C(N(CC)CC)C.[C:19](Cl)(=[O:21])[CH3:20].C([O-])(O)=O.[Na+]>C1COCC1>[Br:1][C:2]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([Cl:11])=[CH:5][C:3]=1[NH:4][C:19](=[O:21])[CH3:20]

참가 물질

6

반응물 4

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 451567062-Bromo-5-chloro-4-methoxybenzenamine

생성물 1

HCID 68535198N-(2-Bromo-5-chloro-4-methoxyphenyl)acetamide수율 69.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4.40 g (18.6 mmol) 2-Bromo-5-chloro-4-methoxy-aniline and 3.1 ml (22.0 mmol) triethylamine were dissolved in 50 ml THF. 1.42 ml (20.0 mmol) acetylchloride were added dropwise at room temperature. The reaction mixture was stirred at room temperature for additional 2 hours, saturated NaHCO3 solution was added and the mixture was extracted with ethyl acetate. Removal of the solvent and crystallisation with ether gave 3.6 g (12.9 mmol, 69%) of the title compound.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. customRemoval of the solvent and crystallisation with ether

출처 및 근거

ORD 기록
ord-7277291a1405423487eb8888b8c9f8f1
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07645760B2

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