Ammonium Chloride → 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

HRID 1991342노트

반응식

HRID 1991342 반응식
[CH2:1]([N:3]1[C:7]2[C:8]([F:15])=[CH:9][C:10]([N+:12]([O-])=O)=[CH:11][C:6]=2[O:5][C:4]1=[O:16])[CH3:2].[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:12][C:10]1[CH:9]=[C:8]([F:15])[C:7]2[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[O:5][C:6]=2[CH:11]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 45095618HCID 45095618, 화합물

생성물 1

HCID 684905716-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

Prepared from 3-ethyl-4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 1.05 g, 4.90 mmol), ammonium chloride (2.62 g, 49 mmol) and iron powder (1.09 g, 19.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.95 g, 99%).

출처 및 근거

ORD 기록
ord-435648196410484ca85b0fc1a3a35735
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07645781B2

반응 노트

불러오는 중…