Ammonium Chloride → 6-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

HRID 1991347노트

반응식

HRID 1991347 반응식
[F:1][C:2]1[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=[C:4]([N+:15]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:15][C:4]1[CH:3]=[C:2]([F:1])[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 68487872HCID 68487872, 화합물

생성물 1

HCID 684896766-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

Prepared from 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 0.87 g, 3.64 mmol), ammonium chloride (1.95 g, 36.4 mmol) and iron powder (0.81 g, 14.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.77 g, 99%).

출처 및 근거

ORD 기록
ord-ebe6659efd9d4d7a824fbaf7cdca53f9
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07645781B2

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