Trifluoromethanesulfonic acid, lithium salt → HCID 86610082, 화합물

HRID 1991348

반응식

HRID 1991348 반응식
[NH2:1][C:2]1[CH:14]=[C:13]([F:15])[C:5]2[N:6]([CH:10]([CH3:12])[CH3:11])[C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[CH3:16][O:17][C:18]([C@@H:20]1[O:22][CH2:21]1)=[O:19].FC(F)(F)S([O-])(=O)=O.[Li+]>C(#N)C>[F:15][C:13]1[C:5]2[N:6]([CH:10]([CH3:12])[CH3:11])[C:7](=[O:9])[O:8][C:4]=2[CH:3]=[C:2]([NH:1][CH2:21][C@@H:20]([OH:22])[C:18]([O:17][CH3:16])=[O:19])[CH:14]=1

참가 물질

5

반응물 3

HCID 3664839Trifluoromethanesulfonic acid, lithium saltHCID 9877347Methyl (2R)-2-oxiranecarboxylateHCID 684896766-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

생성물 1

HCID 86610082HCID 86610082, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Prepared from 6-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one (Step 2, 0.77 g, 3.66 mmol), methyl (2R)-glycidate (0.374 g, 3.66 mmol) and lithium trifluoromethanesulfonate (0.57 g, 3.66 mmol) in acetonitrile (10 ml) according to the method of EXAMPLE 86, Step 8 (0.89 g, 78%); MS for C14H17FN2O5 m/z 313 (M+H)+.

출처 및 근거

ORD 기록
ord-9c8b418560cc45f8a477ab070b52d986
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07645781B2

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