Thionyl Chloride → 3,4-Difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester

HRID 1991917노트

반응식

HRID 1991917 반응식
[C:1]([CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)=[CH:8][CH:7]=1)(O)=[O:2].S(Cl)([Cl:25])=O>C(Cl)Cl>[Cl:25][C:1]([CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)=[CH:8][CH:7]=1)=[O:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 685379543,4-Difluoro-benzoic acid 4-(2-carboxy-vinyl)-phenyl ester

생성물 1

HCID 723620523,4-Difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester수율 90%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
35 °C

실험 절차

About 10 g (about 21.68 mmol) of 3,4-difluoro-benzoic acid 4-(2-carboxy-vinyl)-phenyl ester was dissolved in about 200 ml of methylene chloride, and about 2.84 g (23.848 mmol) of thionyl chloride (SOCl2) was added thereto. Thereafter, the reaction mixture was stirred at about 35° C. for about 6 hours, followed by removing the solvent. Subsequently, a vacuum drying process was conducted, thus obtaining the desired compound (Yield about 90%).

후처리

  1. customby removing the solvent
  2. customSubsequently, a vacuum drying process

출처 및 근거

ORD 기록
ord-72af5323641546aea381b79ab4b5cbc8
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07646014B2

반응 노트

불러오는 중…