참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 7-Ethoxymethyl-3-methylxanthine | HCID 13747684 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-Ethoxymethyl-1-ethyl-3-methylxanthine | HCID 19689194 | — |
반응 단계
30 g (0.134 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of absolute DMF with 25 g (0.161 mol) of ethyl iodide and 22.2 g (0.161 mol) of potassium carbonate and the mixture was stirred at 70° C. for 5 hours. The solution was filtered and the residue which remained was crystallized in diisopropyl ether. 28.7 g (85% of theory) of the title substance were obtained and employed without purification in Example 4b).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05728686 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-841b9089cd1f4520ba61b48f730e5eeb |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
