Ammonia → 3-Fluoro-4-methylbenzenesulfonamide

반응식

[NH3:1].[F:2][C:3]1[CH:4]=[C:5]([S:10](Cl)(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[CH3:9]>>[F:2][C:3]1[CH:4]=[C:5]([S:10]([NH2:1])(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[CH3:9]

참가 물질

반응물 2

HCID 222Ammonia

HCID 27786003-Fluoro-4-methylbenzene-1-sulfonyl chloride

생성물 1

HCID 20641383-Fluoro-4-methylbenzenesulfonamide

실험 절차

To ˜20 mL of liquid ammonia at −78° C. was added 2.1 g (10 mmol) of 3-fluoro-4-methyl benzenesulfonyl chloride. The excess ammonia was then naturally evaporated to dryness overnight at room temperature. The crude sulfonamide was partitioned methylene chloride (100 mL) and water (100 mL). The aqueous phase was further extracted with methylene chloride. The combined organic extracts were dried over anhydrous sodium sulfate. Evaporation of the solvents afforded 1.9 g of 3-fluoro-4-methylbenzenesulfonamide as a solid.

후처리

customThe excess ammonia was then naturally evaporated to dryness overnight at room temperature
customThe crude sulfonamide was partitioned methylene chloride (100 mL) and water (100 mL)
extractionThe aqueous phase was further extracted with methylene chloride
dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
customEvaporation of the solvents

출처 및 근거

ORD 기록: ord-b6eb31ab78bd44929e99e26a1573795f
출처 데이터셋: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07645771B2

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