Triethylamine → N-(3-Bromo-propyl)-4-cyano-benzenesulfonamide

HRID 1992357노트

반응식

HRID 1992357 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].Br.[Br:14][CH2:15][CH2:16][CH2:17][NH2:18].C(N(CC)CC)C>ClCCl>[Br:14][CH2:15][CH2:16][CH2:17][NH:18][S:9]([C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)(=[O:11])=[O:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 394974-Cyanobenzenesulfonyl chlorideHCID 787013-Bromopropylamine hydrobromide

생성물 1

HCID 43133733N-(3-Bromo-propyl)-4-cyano-benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Cyanobenzenesulfonyl chloride (5 g, 0.0248 mol) was added dropwise to a solution of 3-bromopropylamine hydrobromide (6.61 g, 0.0302 mol) and triethylamine (6.26 g, 0.062 mol) in dry dichloromethane (50 ml) at 0° C. and stirred at room temperature overnight under nitrogen atmosphere. The reaction was quenched with water and extracted with dichloromethane. The organic layer was washed with water, brine and dried over sodium sulfate.

후처리

  1. customThe reaction was quenched with water
  2. extractionextracted with dichloromethane
  3. washThe organic layer was washed with water, brine
  4. dry with materialdried over sodium sulfate

출처 및 근거

ORD 기록
ord-3af1aa919d5c4a828056269fa8c41bc5
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07648985B2

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