Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1992402생성일: 2026년 10월 24일
Acetonitrile → 4-Cyano-N-(2-{7-[2-(2-fluoro-phenoxy)-ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-ethyl)-N-methyl-benzenesulfonamide
https://huagongshe.com/ko/reaction/1992402
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(2-Bromoethoxy)-2-fluorobenzene | HCID 2386106 | — |
| 반응물 | 4-cyano-N-methyl-N-[2-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl)-ethyl]-benzenesulfonamide dihydrochloride | HCID 68520931 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Cyano-N-(2-{7-[2-(2-fluoro-phenoxy)-ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-ethyl)-N-methyl-benzenesulfonamide | HCID 68520800 | 58% |
반응 단계
To 4-cyano-N-methyl-N-[2-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl)-ethyl]-benzenesulfonamide dihydrochloride (0.127 g, 0.30 mmol, prep I above), 1-(2-bromo-ethoxy)-2-fluoro-benzene (0.069 g, 0.315 mmol;) and potassium carbonate (0.145 g, 1.05 mmol) was added acetonitrile (4 mL) and water (0.1 mL). The mixture was heated by microwave irradiation (10 minutes, 160° C.) and was then filtered and evaporated. The crude product was purified by chromatography on silica gel using methanol saturated with ammonia in dichloromethane as eluent, which afforded 85 mg (58.0%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07648985B2 |
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| 출처 데이터셋 | uspto-grants-2010_01 |
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| ORD ID | ord-fec54478f9c04f31973031cb30395e37 |
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| 출처 메모 | uspto-grants-2010_01 |
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