(3-Chlorophenyl)boronic acid → HCID 68535842, 화합물

HRID 1992472

반응식

HRID 1992472 반응식
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([S:29]([CH:32]([CH3:34])[CH3:33])(=[O:31])=[O:30])[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Cl:35][C:36]1[CH:37]=[C:38](B(O)O)[CH:39]=[CH:40][CH:41]=1>>[Cl:35][C:36]1[CH:41]=[C:40]([N:17]2[C:18]3[C:14](=[CH:13][C:12]([C:10]([N:7]4[CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:9][CH2:8]4)=[O:11])=[CH:20][CH:19]=3)[CH:15]=[C:16]2[C:21]([N:23]2[CH2:24][CH2:25][N:26]([S:29]([CH:32]([CH3:34])[CH3:33])(=[O:30])=[O:31])[CH2:27][CH2:28]2)=[O:22])[CH:39]=[CH:38][CH:37]=1

참가 물질

3

반응물 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 68534115[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone

생성물 1

HCID 68535842HCID 68535842, 화합물수율 65%

실험 절차

The title compound was synthesized in analogy to example 5, after stirring for 3.5 days at 35° C., from [5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone (example 15) and 3-chlorophenylboronic acid to afford the desired product as a colorless foam (65%). MS (ISP): 600.4 (M+H)+.

후처리

  1. customThe title compound was synthesized in analogy to example 5

출처 및 근거

ORD 기록
ord-29866ae947b7435590b1211e433a6f9a
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07648979B2

연결된 노트

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