Tetrahydro-4H-pyran-4-one → (4-Methanesulfonyl-piperazin-1-yl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepane-1-carbonyl]-1H-indol-2-yl}-methanone

HRID 1992496

반응식

C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][C:21]([C:26]([N:28]2[CH2:33][CH2:32][N:31]([S:34]([CH3:37])(=[O:36])=[O:35])[CH2:30][CH2:29]2)=[O:27])=[CH:20]3)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[O:38]1[CH2:43][CH2:42][C:41](=O)[CH2:40][CH2:39]1>>[CH3:37][S:34]([N:31]1[CH2:30][CH2:29][N:28]([C:26]([C:21]2[NH:22][C:23]3[C:19]([CH:20]=2)=[CH:18][C:17]([C:15]([N:11]2[CH2:12][CH2:13][CH2:14][N:8]([CH:41]4[CH2:42][CH2:43][O:38][CH2:39][CH2:40]4)[CH2:9][CH2:10]2)=[O:16])=[CH:25][CH:24]=3)=[O:27])[CH2:33][CH2:32]1)(=[O:36])=[O:35]

참가 물질

반응물 2

HCID 121599Tetrahydro-4H-pyran-4-one

HCID 685367474-[2-(4-methanesulfonyl-piperazine-1-carbonyl)-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

생성물 1

HCID 68534110(4-Methanesulfonyl-piperazin-1-yl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepane-1-carbonyl]-1H-indol-2-yl}-methanone

실험 절차

The title compound was synthesized in analogy to example 47, from 4-[2-(4-methanesulfonyl-piperazine-1-carbonyl)-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester and tetrahydro-4H-pyran-4-one. Yellow gum. MS (m/z): 518.3 (M+H)+.

출처 및 근거

ORD 기록: ord-5ab03cfefd964cbabe49dab22e9a3bb2
출처 데이터셋: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07648979B2

연결된 노트

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