HCID 57445398, 화합물 → 4-(6-Benzyl-pyridazin-3-yl)-2-fluoro-phenol

HRID 1993365노트

반응식

HRID 1993365 반응식
[CH2:1]([C:8]1[N:9]=[N:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[C:16]([F:22])[CH:15]=2)=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>B(Br)(Br)Br.C(Cl)Cl>[CH2:1]([C:8]1[N:9]=[N:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([F:22])[CH:15]=2)=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 57445398HCID 57445398, 화합물

생성물 1

HCID 1360707044-(6-Benzyl-pyridazin-3-yl)-2-fluoro-phenol

시약·촉매·용매 1

HCID 22277759Boron tribromide dichloromethane용매

실험 절차

A solution of 3-benzyl-6-(3-fluoro-4-methoxy-phenyl)-pyridazine (Step 2, 1.5 g, 5.1 mmol) in 25 mL of 1 M BBr3/CH2Cl2 was stirred at RT for 16 h. The solution was then concentrated in vacuo and the residue was re-dissolved in 100 mL of EtOAc. The organic phase was washed with 40 mL of water followed by 40 mL of brine, dried over Na2SO4 and concentrated in vacuo to give the title compound. The solid has poor solubility in EtOAc and CH2Cl2 and was washed with 50% EtOAc/hexane and then used in the next step (yellow solid). MS (ESI pos. ion) m/z: 281.3 (M+H). Calc'd Exact Mass for C17H13FN2O: 280.30.

후처리

  1. concentrationThe solution was then concentrated in vacuo
  2. dissolutionthe residue was re-dissolved in 100 mL of EtOAc
  3. washThe organic phase was washed with 40 mL of water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f6694c79ff8a41e8b7738bd2e6628c63
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652009B2

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