Pyridinium chloride → 2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol

HRID 1993368노트

반응식

HRID 1993368 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[N:12][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[N:12][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

참가 물질

3

반응물 2

HCID 10176127Pyridinium chlorideHCID 574454003-(3-Fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine

생성물 1

HCID 1360707052-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol

반응 조건

온도
170 °C

실험 절차

A mixture of 3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine (Step 1, 0.60 g, 2.0 mmol) and pyridine hydrochloride (3 g) was heated in an oil bath at 170° C. for 8 h. The sublimed pyridine hydrochloride on the top of the reaction flask was removed, and the residue (0.65 g) was used in the next step without further purification. MS (ESI pos. ion) m/z: 283.1 (M+H). Calc'd Exact Mass for C16H11FN2O2: 282.27.

후처리

  1. customThe sublimed pyridine hydrochloride on the top of the reaction flask was removed
  2. customthe residue (0.65 g) was used in the next step without further purification

출처 및 근거

ORD 기록
ord-0e6be287f8ed412a89bbf6605cbdc0f7
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652009B2

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