4-Benzoyl-1-(3-fluoro-4-methoxyphenyl)pyrrolidin-2-one → 4-Benzoyl-1-(3-fluoro-4-hydroxyphenyl)pyrrolidin-2-one

HRID 1993386노트

반응식

HRID 1993386 반응식
[C:1]([CH:9]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[C:16]([F:22])[CH:15]=2)[C:11](=[O:23])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>B(Br)(Br)Br.C(Cl)Cl>[C:1]([CH:9]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([F:22])[CH:15]=2)[C:11](=[O:23])[CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 574454054-Benzoyl-1-(3-fluoro-4-methoxyphenyl)pyrrolidin-2-one

생성물 1

HCID 574454064-Benzoyl-1-(3-fluoro-4-hydroxyphenyl)pyrrolidin-2-one

시약·촉매·용매 1

HCID 22277759Boron tribromide dichloromethane용매

실험 절차

A mixture of 4-benzoyl-1-(3-fluoro-4-methoxyphenyl)pyrrolidin-2-one (Step 2, 1.0 g, 3.2 mmol) in 20 mL of 1 M BBr3/CH2Cl2 was stirred at RT for 16 h. The solution was concentrated in vacuo and the residue was diluted with 50 mL of MeOH and concentrated in vacuo again. The resulting white solid was washed with 50% EtOAc/hexane to give the title compound. MS (ESI pos. ion) m/z: 300.4 (M+H). Calc'd Exact Mass for C17H14FNO3: 299.3.

후처리

  1. concentrationThe solution was concentrated in vacuo
  2. additionthe residue was diluted with 50 mL of MeOH
  3. concentrationconcentrated in vacuo again
  4. washThe resulting white solid was washed with 50% EtOAc/hexane

출처 및 근거

ORD 기록
ord-7d0ece2889824c4d80fdf5d50a9d8af8
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652009B2

반응 노트

불러오는 중…