Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1993401생성일: 2026년 10월 25일
Diisopropylethylamine → 4-(6-Oxo-1,6-dihydro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1993401
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 반응물 | 6-Chloropyrimidin-4-ol | HCID 135445478 | — |
| 용매 | (+-)-2-Butanol | HCID 6568 | — |
| 생성물 | 4-(6-Oxo-1,6-dihydro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 136102561 | 74.1% |
반응 단계
To a suspension of 6-chloro-3H-pyrimidin-4-one (˜0.23 mol) in sec-butanol (525 mL) was added ethyldiisopropylamine (49.7 mL, 0.3 mol) and BOC-piperazine (available from Aldrich; 55.9 g, 0.3 mol). The reaction was stirred at 80° C. for 8 hours, and then allowed to cool to room temperature. The crude reaction mixture was filtered, and washed with sec-butanol to give 4-(6-oxo-1,6-dihydro-pyrimidin-4-yl) -piperazine-1-carboxylic acid tert-butyl ester (47.8 g, 74%) LCMS Purity=100% (Rt=1.42). 1H NMR (400 MHz, CDCl3) δ 7.80 (s, 1H), 5.34 (s, 1H), 3.56-3.46 (m, 4H), 3.46-3.38 (m, 4H), 1.38 (s, 9H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07652013B2 |
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| 출처 데이터셋 | uspto-grants-2010_01 |
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| ORD ID | ord-2f222982204644f79249ebff68ab0e53 |
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| 출처 메모 | uspto-grants-2010_01 |
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