Water → Benzyl 3-hydroxy-2,2-dimethylpropanoate

HRID 1993672

반응식

HRID 1993672 반응식
[OH-].[K+].O[C:4]([CH3:10])([CH2:8][OH:9])[C:5]([OH:7])=[O:6].[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O.[CH3:20]N(C=O)C>C(OCC)(=O)C>[CH2:11]([O:7][C:5](=[O:6])[C:4]([CH3:10])([CH3:20])[CH2:8][OH:9])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

7

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 7498Benzyl BromideHCID 14797Potassium HydroxideHCID 5607812-Methylglyceric acid

생성물 1

HCID 18922595Benzyl 3-hydroxy-2,2-dimethylpropanoate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

반응 조건

온도
100 °C

실험 절차

Add potassium hydroxide (486.7 mmol, 32.1 g) over a solution of 2,3-dihydroxy-2-methyl-propionic acid (423.2 mmol, 50 g) in 300 mL of DMF. Stir the solution for 1 hour at 100° C., then add benzyl bromide. Stir the solution overnight. Cool the mixture and dilute with ethyl acetate. Wash organic layer with water. Wash aqueous layer with ethyl acetate several times. Combine organic layers and dry over sodium sulfate, filter and concentrate under reduced pressure.

후처리

  1. stirringStir the solution overnight
  2. temperatureCool the mixture
  3. dry with materialCombine organic layers and dry over sodium sulfate
  4. filtrationfilter
  5. concentrationconcentrate under reduced pressure

출처 및 근거

ORD 기록
ord-47c92e3d87394898bcbcff1ac92ca457
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652015B2

연결된 노트

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