Bromine → HCID 178510531, 화합물

HRID 1993821

반응식

HRID 1993821 반응식
[C:1]([CH:3]([C:7](=[S:25])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=2[Cl:23])=[C:11]([F:24])[CH:10]=1)[C:4]([NH2:6])=[O:5])#[N:2].BrBr>C(OCC)(=O)C>[Cl:23][C:17]1[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:16]=1[O:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:7]2[S:25][N:6]=[C:4]([OH:5])[C:3]=2[C:1]#[N:2])=[CH:10][C:11]=1[F:24]

참가 물질

4

반응물 2

HCID 24408BromineHCID 597977082-Cyano-2-[4-(2,5-dichloro-phenoxy)-3-fluoro-phenylthiocarbamoyl]-acetamide

생성물 1

HCID 178510531HCID 178510531, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

2-Cyano-2-[4-(2,5-dichloro-phenoxy)-3-fluoro-phenylthiocarbamoyl]-acetamide (1.6 g, 4 mmol) was dissolved in anhydrous ethyl acetate (60 ml) and a solution of bromine (0.2 ml, 4 mmol) in anhydrous ethyl acetate (10 ml) was added dropwise into the mixture with stirring at room temperature. After addition, the reaction mixture was stirred for another 3 hours. The precipitate was filtered and the solid was washed with ethyl ether and suspended in a saturated sodium bicarbonate with stirring for 10 min. The solid was filtered, then washed with water and dried in vacuo to afford a white powder.

후처리

  1. additionAfter addition
  2. stirringthe reaction mixture was stirred for another 3 hours
  3. filtrationThe precipitate was filtered
  4. washthe solid was washed with ethyl ether
  5. stirringwith stirring for 10 min
  6. filtrationThe solid was filtered
  7. washwashed with water
  8. customdried in vacuo
  9. customto afford a white powder

출처 및 근거

ORD 기록
ord-7d752b218a7a4891947964a1a7ef3a59
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652047B2

연결된 노트

불러오는 중…