HCID 66877304, 화합물 → trans-(5-Chloro-indan-2-ylmethyl)-[3-(2,5-dimethyl-benzoimidazol-1-yl)-cyclopentyl]-amine

HRID 1993880노트

반응식

HRID 1993880 반응식
Cl.[CH3:2][C:3]1[N:7]([C@H:8]2[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9]2)[C:6]2[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:5]=2[N:4]=1.[Cl:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[CH2:25][CH:24]([CH:29]=O)[CH2:23]2>>[Cl:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[CH2:25][CH:24]([CH2:29][NH:13][C@H:10]1[CH2:11][CH2:12][C@H:8]([N:7]3[C:6]4[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:5]=4[N:4]=[C:3]3[CH3:2])[CH2:9]1)[CH2:23]2

참가 물질

3

반응물 2

HCID 66877304HCID 66877304, 화합물HCID 86620957HCID 86620957, 화합물

생성물 1

HCID 66876580trans-(5-Chloro-indan-2-ylmethyl)-[3-(2,5-dimethyl-benzoimidazol-1-yl)-cyclopentyl]-amine

실험 절차

This compound was prepared from trans-3-(2,5-dimethyl-benzoimidazol-1-yl)-cyclopentylamine hydrochloride and 5-chloro-indan-2-carbaldehyde using the same reductive amination method described in previous example. 1H-NMR is consistent with the assigned structure. LC-MS showed a single peak, C24H28ClN3 (m/e) calcd 393.1972, obsd 394.2 (M+H).

출처 및 근거

ORD 기록
ord-b27444cb89124cfe91189d1c7561baeb
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652053B2

반응 노트

불러오는 중…