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Potassium Carbonate → Tert-butyl 13-cyclohexyl-3-methoxy-6-(4-(methoxycarbonyl)-1,3-oxazol-5-yl)-7h-indolo[2,1-a][2]benzazepine-10-carboxylate

HRID 1994088
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HRID 1994088 반응식
[C:1]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]2[C:12]([CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)=[C:13]3[C:19]4[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:18]=4[CH:17]=[C:16]([C:26](O)=[O:27])[CH2:15][N:14]3[C:29]=2[CH:30]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[N+:43]([CH2:45][C:46]([O:48][CH3:49])=[O:47])#[C-:44].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=O)C=CC=CC=1>CN(C=O)C>[CH:31]1([C:12]2[C:11]3[CH:10]=[CH:9][C:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[CH:30][C:29]=3[N:14]3[CH2:15][C:16]([C:26]4[O:27][CH:44]=[N:43][C:45]=4[C:46]([O:48][CH3:49])=[O:47])=[CH:17][C:18]4[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:19]=4[C:13]=23)[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1
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참가 물질

6

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HCID 11430Potassium CarbonateHCID 199401P,P-Diphenylphosphinic azideHCID 547815Methyl isocyanoacetateHCID 5771220210-(tert-butoxycarbonyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

생성물 1

HCID 25211328Tert-butyl 13-cyclohexyl-3-methoxy-6-(4-(methoxycarbonyl)-1,3-oxazol-5-yl)-7h-indolo[2,1-a][2]benzazepine-10-carboxylate
수율 18.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

10-(tert-butoxycarbonyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid (1.00 g, 2.051 mmol) was dissolve in DMF (10 ml) and potassium carbonate (0.624 g, 4.51 mmol) was added to the reaction followed by methyl isocyanoacetate (0.24 ml, 2.64 mmol). The reaction was stirred under a nitrogen atmosphere at room temperature for approximately 5 minutes then cooled to 0 C. Diphenylphosphoryl azide (0.5 ml, 2.320 mmol) was slowly added to the reaction over 10 minutes. The reaction was stirred at 0 C under a nitrogen atmosphere and allowed to slowly warm to room temperature overnight. Dilute reaction. with 100 ml of benzene/ethyl acetate (1:1) and wash with water. Back extract aqueous layer using ethyl acetate. Combine organic extracts and wash successively with 0.1M aqueous citric acid, saturated aqueous sodium bicarbonate and then brine and dry over magnesium sulfate. Filter and remove volatiles in vacuuo. Chromatograph on 43.4 g of silica gel slurry packed in 5% ethyl acetate/dichloromethane. Elute with 5% ethyl acetate/dichloromethane. Combination of pure product fractions and removal of volatiles in vacuuo yielded 215 mg of an amorphous yellow solid. Combination of less pure fractions yielded an additional 189 mg of product with purity greater than 92%. 1H NMR (500 MHz, CHLOROFORM-D) δ ppm 1.11-1.29 (m, 2H) 1.30-1.48 (m, 3H) 1.57 (s, 2H) 1.61 (s, 10H) 1.69-1.80 (m, 2H) 1.86-1.98 (m, 1H) 1.99-2.13 (m, 4H) 2.76-2.90 (m, 1H) 3.92 (s, 3H) 3.98 (s, 3H) 4.47 (d, J=12.82 Hz, 1H) 5.84 (d, J=14.65 Hz, 1H) 7.02 (d, J=2.44 Hz, 1H) 7.07 (dd, J=8.55, 2.75 Hz, 1H) 7.53 (d, J=8.55 Hz, 1H) 7.65-7.71 (m, 1H) 7.82 (d, J=8.24 Hz, 1H) 7.87 (s, 1H) 8.08 (s, 1H) 8.16 (s, 1H). LC-MS retention time 2.75 min; m/z (MH+). LC data was recorded on a Shimadzu LC-10AS liquid chromatograph equipped with a Waters Xterra MS 7u C18 3.0×50 mm column using a SPD-10AV UV-Vis detector at a detector wave length of 220 nM. The elution conditions employed a flow rate of 5 ml/min, a gradient of 100% solvent A/0% solvent B to 0% solvent A/100% solvent B, a gradient time of 3 min, a hold time of 0 min, and an analysis time of 3 min where solvent A was 5% acetonitrile/95% H2O/10 mM ammonium acetate and solvent B was 5% H2O/95% acetonitrile/10 mM ammonium acetate. MS data was determined using a Micromass Platform for LC in electrospray mode.

후처리

  1. temperaturethen cooled to 0 C
  2. stirringThe reaction was stirred at 0 C under a nitrogen atmosphere
  3. temperatureto slowly warm to room temperature overnight
  4. additionDilute
  5. customreaction
  6. washwith 100 ml of benzene/ethyl acetate (1:1) and wash with water
  7. extractionBack extract aqueous layer
  8. washCombine organic extracts and wash successively with 0.1M aqueous citric acid, saturated aqueous sodium bicarbonate
  9. dry with materialbrine and dry over magnesium sulfate
  10. filtrationFilter
  11. customremove volatiles in vacuuo
  12. washElute with 5% ethyl acetate/dichloromethane
  13. customCombination of pure product fractions and removal of volatiles in vacuuo

출처 및 근거

ORD 기록
ord-3a6e2db071cd4a3393e93f73f179dade
출처 데이터셋
uspto-grants-2010_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07652004B2

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