Methyl 4-nitro-2-(trifluoromethyl)benzoate → Methyl 4-amino-2-(trifluoromethyl)benzoate

HRID 1994124노트

반응식

HRID 1994124 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:14]([F:17])([F:16])[F:15])[CH:5]=1)([O-])=O.O.O.[Sn](Cl)(Cl)(Cl)Cl>CCOC(C)=O>[NH2:1][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:14]([F:15])([F:16])[F:17])[CH:5]=1

참가 물질

4

반응물 2

HCID 46311176Methyl 4-nitro-2-(trifluoromethyl)benzoateHCID 85782573Tin tetrachloride dihydrate

생성물 1

HCID 46311081Methyl 4-amino-2-(trifluoromethyl)benzoate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Methyl 4-nitro-2-(trifluoromethyl)benzoate (5.20 g, 20.9 mmol) was dissolved in EtOAc (100 mL) and tin chloride dihydrate (9.41 g, 41.7 mmol) was added to the reaction mixture. The reaction was heated at reflux for 2 h. The crude reaction mixture was purified by column chromatography (SiO2, EtOAc/hexanes) to give the title compound. LCMS: (FA) ES− 218.4 (M−1).

후처리

  1. temperatureThe reaction was heated
  2. temperatureat reflux for 2 h
  3. customThe crude reaction mixture
  4. customwas purified by column chromatography (SiO2, EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-5142fc929ec341fcbdd87482b31c9991
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652041B2

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