Einecs 211-027-4 → 1-Butyl-5,6-dimethyl-3-hydroxy-2-pyridone

HRID 1994230노트

반응식

HRID 1994230 반응식
[Cl-].[NH+]1C=CC=CC=1.[CH2:8]([N:12]1[C:17]([CH3:18])=[C:16]([CH3:19])[CH:15]=[C:14]([O:20]C)[C:13]1=[O:22])[CH2:9][CH2:10][CH3:11]>C(OCC)C>[CH2:8]([N:12]1[C:17]([CH3:18])=[C:16]([CH3:19])[CH:15]=[C:14]([OH:20])[C:13]1=[O:22])[CH2:9][CH2:10][CH3:11]

참가 물질

4

반응물 2

HCID 69401Einecs 211-027-4HCID 222665381-Butyl-5,6-dimethyl-3-methoxy-2-pyridone

생성물 1

HCID 222665251-Butyl-5,6-dimethyl-3-hydroxy-2-pyridone수율 81.3%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
200 °C

실험 절차

Pyridinium chloride (293 mg) was added to 1-butyl-5,6-dimethyl-3-methoxy-2-pyridone (1-004-07) (124 mg), and the reaction mixture was heated with stirring in an oil bath at 200° C. under nitrogen atmosphere. After 30 min, the reaction mixture was dissolved in diethyl ether and water, extracted twice with diethyl ether, washed once with water, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 1-butyl-5,6-dimethyl-3-hydroxy-2-pyridone (1-004-08) (94 mg, 81%, m.p.: 112-116° C.)

후처리

  1. temperaturethe reaction mixture was heated
  2. extractionwater, extracted twice with diethyl ether
  3. washwashed once with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3259e34e67a14600855429d5f3fd09ac
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652141B2

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