Methyl 6-methoxy-5-nitronicotinate → Methyl 5-amino-6-methoxypyridine-3-carboxylate
반응식
[CH3:1][O:2][C:3]1[C:12]([N+:13]([O-])=O)=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:4]=1.[H][H]>C(OCC)(=O)C.[Pd]>[NH2:13][C:12]1[C:3]([O:2][CH3:1])=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]참가 물질
5
실험 절차
A solution of methyl 6-methoxy-5-nitronicotinate (5.4 g) in ethyl acetate (120 mL) is hydrogenated using 5% palladium on carbon (1 g) as catalyst. When hydrogen uptake ceased the mixture is filtered through a pad of diatomaceous earth and the filtrate evaporated. The residue is triturated with n-pentane and methyl t-butyl ether to give methyl 5-amino-6-methoxynicotinoate (4.3 g) as a light-brown solid, m.p. 108-9° C. [Elemental analysis: —C, 52.99; H, 5.49; N, 15.25%. calculated: —C, 52.74; H, 5.53; N, 15.38%.]
후처리
- filtrationis filtered through a pad of diatomaceous earth
- customthe filtrate evaporated
- customThe residue is triturated with n-pentane and methyl t-butyl ether
출처 및 근거
- ORD 기록
- ord-c349f04fa2c744e3a6607af21a9c0caf
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07652144B2
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