Thionyl Chloride → 2-[2-Nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionyl Chloride

HRID 1995035

반응식

HRID 1995035 반응식
[N+:1]([C:4]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:18]=2[Cl:27])=[CH:12][C:5]=1[O:6][CH:7]([CH3:11])[C:8](O)=[O:9])([O-:3])=[O:2].S(Cl)([Cl:30])=O>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:18]=2[Cl:27])=[CH:12][C:5]=1[O:6][CH:7]([CH3:11])[C:8]([Cl:30])=[O:9])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 35679032-{5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy}propanoic acid

생성물 1

HCID 131006842-[2-Nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionyl Chloride

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
67 °C

실험 절차

2-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionic acid (100 grams) and toluene (40 ml) were charged into a glass reaction vessel equipped with a magnetic stirrer. The mixture was heated on a steam bath until a solution was obtained. The solution was allowed to cool and thionyl chloride (100 ml) was added dropwise with stirring. After the addition was completed, the mixture was warmed to 67° C. with continued stirring for a period of about 21/2 hours. After this time the mixture was stripped of solvent in a rotary evaporator under reduced pressure leaving as the residue 105 grams of the desired product, 2-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionyl chloride as a burgundy colored viscous oil.

후처리

  1. customequipped with a magnetic stirrer
  2. temperatureThe mixture was heated on a steam bath until a solution
  3. customwas obtained
  4. temperatureto cool
  5. additionAfter the addition
  6. stirringwith continued stirring for a period of about 21/2 hours
  7. customAfter this time the mixture was stripped of solvent in a rotary evaporator under reduced pressure

출처 및 근거

ORD 기록
ord-f6e812eecfe14b80af0abbeb1904c913
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04402729

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