Triethyl orthoacetate → 3-Methyl-6-phenyl[1,2,4]triazolo[4,3-a]pyrazine

HRID 1995062

반응식

HRID 1995062 반응식
[NH:1]([C:3]1[CH:8]=[N:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][N:4]=1)[NH2:2].[C:15](OCC)(OCC)(OCC)[CH3:16]>>[C:9]1([C:6]2[N:7]=[CH:8][C:3]3[N:4]([C:15]([CH3:16])=[N:2][N:1]=3)[CH:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 66221Triethyl orthoacetateHCID 131998672-Hydrazinyl-5-phenylpyrazine

생성물 1

HCID 131998743-Methyl-6-phenyl[1,2,4]triazolo[4,3-a]pyrazine

실험 절차

A solution of 0.5 g. (0.0027 mole) of 2-hydrazino-5-phenylpyrazine in 5.0 ml. of triethyl orthoacetate is heated under reflux for 5 hours. The crystalline product precipitates from the hot reaction solution, and at the end of the heating period the mixture is cooled and the product is collected. Recrystallization from ethanol gives 0.36 g. of the product of the example, m.p. 192°-195° C.

후처리

  1. temperatureunder reflux for 5 hours
  2. customThe crystalline product precipitates from the hot reaction solution
  3. temperatureat the end of the heating period the mixture is cooled
  4. customthe product is collected
  5. customRecrystallization from ethanol
  6. customgives 0.36 g

출처 및 근거

ORD 기록
ord-d0914a405b454da587388b08131ff14a
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04402958

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