2,5-Dimethoxytetrahydrofuran → HCID 70532416, 화합물

HRID 1995322노트

반응식

HRID 1995322 반응식
[NH2:1][C:2]1[C:13]2=[C:14]3[N:9]([CH:10]([CH3:15])[CH2:11][CH2:12]2)[CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6](=[O:19])[C:5]3=[CH:4][C:3]=1[F:20].CO[CH:23]1[CH2:27][CH2:26][CH:25](OC)O1>C(O)(=O)C>[OH2:17].[F:20][C:3]1[CH:4]=[C:5]2[C:14]3[N:9]([CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6]2=[O:19])[CH:10]([CH3:15])[CH2:11][CH2:12][C:13]=3[C:2]=1[N:1]1[CH:23]=[CH:27][CH:26]=[CH:25]1

참가 물질

4

반응물 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 131891281H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 8-amino-9-fluoro-6,7-dihydro-5-methyl-1-oxo-

생성물 1

HCID 70532416HCID 70532416, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a suspension of 1.0 g of 8-amino-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid in 20 ml of warm galcial acetic acid was added 1.0 g 2,5-dimethoxytetrahydrofuran. The mixture was heated at reflux for 30 minutes. The product which precipitated was separated by filtration and washed with water to provide yellowish-white crystals of 6,7-dihydro-9-fluoro-5-methyl-1-oxo-8-(1-pyrryl)-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrate, m.p. 300° C. Analysis: Calculated for C18H15FN2O3.1/3H2O: %C, 65.0; %H, 4.7; %N, 8.4; Found: %C, 64.8; %H, 4.5; %N, 8.4. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 30 minutes
  3. customThe product which precipitated
  4. customwas separated by filtration
  5. washwashed with water

출처 및 근거

ORD 기록
ord-39a70a72e5d649c1b721f29f5c25224c
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04404207

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