4-Chloro-6-methylpyridine-2-carboxylic acid → HCID 178426117, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([OH:11])=O)[CH:3]=1.[NH2:12][C:13]1[NH:17][N:16]=[N:15][N:14]=1>>[NH:14]1[C:13]([NH:12][C:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([CH3:8])[N:5]=2)=[O:11])=[N:17][N:16]=[N:15]1

참가 물질

반응물 2

HCID 114010234-Chloro-6-methylpyridine-2-carboxylic acid

HCID 178509299HCID 178509299, 화합물

생성물 1

HCID 178426117HCID 178426117, 화합물수율 68.7%

실험 절차

0.68 g of 4-chloro-6-methyl-2-pyridinecarboxylic acid, 0.67 g of N,N'-carbonyldiimidazole and 0.37 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and ethanol, whereby 0.65 g of N-(5-tetrazolyl)-4-chloro-6-methyl-2-pyridinecarboxamide is obtained.

후처리

customThe crude product thus obtained
customis recrystallized from a mixture of dimethylformamide and ethanol

출처 및 근거

ORD 기록: ord-a4cc4b8d7f424794ad10242e96356b48
출처 데이터셋: uspto-grants-1983_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04404214

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