Phenyl phosphorodiamidate → 6-Methyl-5-phenylpyridin-2-amine
반응식
[CH3:1][C:2]1[NH:7][C:6](=O)[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C1(OP(N)([NH2:24])=O)C=CC=CC=1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:1][C:2]1[N:7]=[C:6]([NH2:24])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1참가 물질
4
실험 절차
A mixture of 6-methyl-5-phenyl-2-pyridone (12.0 grams) and phenylphosphorodiamidate (14.4 grams) in 300 ml diphenyl ether was heated for 19-20 hours at approximately 220°-225° [250]° C. After cooling, the reaction mixture was chromatographed over silica gel with ethyl acetate. A total of 0.8 gram, of desired product was collected and recrystallized from dichloromethane/petroleum ether, m.p. 110°-113° C.
후처리
- temperaturewas heated for 19-20 hours at approximately 220°-225° [250]° C
- temperatureAfter cooling
- customthe reaction mixture was chromatographed over silica gel with ethyl acetate
- customA total of 0.8 gram, of desired product was collected
- customrecrystallized from dichloromethane/petroleum ether, m.p. 110°-113° C.
출처 및 근거
- ORD 기록
- ord-8748852fa503406d89d41ac41d6f08d2
- 출처 데이터셋
- uspto-grants-1983_09
- 특허 번호
- US04405552
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