Rmi 82249 → 2H-Imidazol-2-one, 1,3-dihydro-4-(4-hydroxybenzoyl)-5-methyl-

HRID 1995657

반응식

HRID 1995657 반응식
Cl.N1C=CC=CC=1.C[O:9][C:10]1[CH:24]=[CH:23][C:13]([C:14]([C:16]2[NH:17][C:18](=[O:22])[NH:19][C:20]=2[CH3:21])=[O:15])=[CH:12][CH:11]=1>>[OH:9][C:10]1[CH:24]=[CH:23][C:13]([C:14]([C:16]2[NH:17][C:18](=[O:22])[NH:19][C:20]=2[CH3:21])=[O:15])=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 132464Rmi 82249HCID 10176127Pyridinium chloride

생성물 1

HCID 155675402H-Imidazol-2-one, 1,3-dihydro-4-(4-hydroxybenzoyl)-5-methyl-

실험 절차

To a melt of 26 g (0.23 mole) of pyridine hydrochloride at 200°-205° C. is added 5.3 g (0.023 mole) of 1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one and the mixture is stirred mechanically for 30 minutes. The reaction mixture is poured on ice-2NHCl. The resulting precipitate is washed with water and recrystallized from isopropanol-water to give the title compound. M.P. >300° C. λ(max)(methanol) 320 nm (ε=13,200).

후처리

  1. additionThe reaction mixture is poured on ice-2NHCl
  2. washThe resulting precipitate is washed with water
  3. customrecrystallized from isopropanol-water

출처 및 근거

ORD 기록
ord-2e3624f8982244ca9a7a152c272b6bad
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04405635

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