5-[(4-Chlorophenyl)methoxy]-2-nitropyridine → 5-[(4-Chlorophenyl)methoxy]pyridin-2-amine

HRID 1995821노트

반응식

HRID 1995821 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][C:8]2[CH:9]=[CH:10][C:11]([N+:14]([O-])=O)=[N:12][CH:13]=2)=[CH:4][CH:3]=1>O.CO>[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([O:7][CH2:6][C:5]2[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:13][N:12]=1

참가 물질

4

반응물 1

HCID 204861295-[(4-Chlorophenyl)methoxy]-2-nitropyridine

생성물 1

HCID 204861125-[(4-Chlorophenyl)methoxy]pyridin-2-amine

시약·촉매·용매 2

HCID 962Water촉매HCID 887Methanol용매2회

실험 절차

A mixture of 5-(4-chlorobenzyloxy)-2-nitropyridine (0.5 g), Na2S (0.25 g) and methanol (12 ml) is heated to reflux for about 3 hours. Then, a few drops of water is added and refluxing continued about 15 hours. After cooling, the reaction is diluted with methanol, filtered through celite and stripped. The concentrate is taken up in CHCl3, washed with water, dried and stripped giving 2-amino-5-(4-chlorobenzyloxy)pyridine.

후처리

  1. temperatureis heated
  2. temperatureto reflux for about 3 hours
  3. temperaturerefluxing
  4. temperatureAfter cooling
  5. filtrationfiltered through celite
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-a45c41810db74af795ff44402984949c
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04406690

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