Ammonium Chloride → Pyridine-4-amidine hydrochloride

HRID 1995903

반응식

HRID 1995903 반응식
[NH4+:1].[Cl-:2].[C:3](=[NH:13])(OCC)[C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1>C(O)C>[ClH:2].[C:3]([NH2:13])(=[NH:1])[C:4]1[CH:5]=[CH:6][N:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 25517Ammonium ChlorideHCID 12263946Ethyl isonicotinimidate

생성물 1

HCID 2776844Pyridine-4-amidine hydrochloride수율 59.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

An aqueous solution of NH4Cl (26.9 g) is added to a solution of ethyl isonicotinimidate (75.5 g) in ethanol (325 ml). The reaction mixture is heated to reflux for four hours and stirred overnight. A white precipitate is filtered, washed with the mother liquor, dried at 90° C. under house vacuum for 8 hours, yielding 47 g of a white crystalline solid mp. 233°-237° C. The precipitate is dried overnight yielding 44.2 g of the desired hydrochloride, m.p. 237°-240° C.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux for four hours
  3. filtrationA white precipitate is filtered
  4. washwashed with the mother liquor
  5. customdried at 90° C. under house vacuum for 8 hours

출처 및 근거

ORD 기록
ord-ae906ffa048544caa43cf4791a8cb38d
출처 데이터셋
uspto-grants-1983_09
특허 번호
US04406897

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