Benzyl Bromide → 2-(Benzyloxy)-1-methoxy-4-nitrobenzene

HRID 19987

반응식

HRID 19987 반응식
C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[OH:18].[CH2:19](Br)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CC(C)=O>[CH2:19]([O:18][C:10]1[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:9]=1[O:8][CH3:7])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 694712-Methoxy-5-nitrophenol

생성물 1

HCID 53140362-(Benzyloxy)-1-methoxy-4-nitrobenzene수율 96.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Potassium carbonate (1.65 gm; 12 mmol) was added to a solution of 2-methoxy-5-nitro phenol (1.69 g; 10 mmol) and benzyl bromide (1.71 gm; 10 mmol) in acetone (60 ml). The reaction mixture was refluxed for 12 hours. The solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate (150 ml) and water (50 ml). The ethyl acetate layer was separated, washed with water (2×50 ml), dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.5 g of 1-Benzyloxy-2-methoxy-5-nitrobenzene (Yield=96.5%)

후처리

  1. temperatureThe reaction mixture was refluxed for 12 hours
  2. customThe solvent was removed under reduced pressure
  3. customthe residue was partitioned between ethyl acetate (150 ml) and water (50 ml)
  4. customThe ethyl acetate layer was separated
  5. washwashed with water (2×50 ml)
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customRemoval of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-dfb5a266abc740b7aeafad57481660b5
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745490B2

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