2-Pyridineacetic acid → 2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide

HRID 2000735

반응식

HRID 2000735 반응식
[NH2:1][c:2]1[s:18][c:5]([CH2:6][C@@H:7]2[CH2:11][C@H:10]([c:12]3[s:17][c:15]([NH2:16])[n:14][n:13]3)[CH2:9][CH2:8]2)[n:4][n:3]1.[OH:19][C:20]([CH2:22][c:23]1[n:28][cH:27][cH:26][cH:25][cH:24]1)=[O:21]>>[O:21]=[C:20]([NH:1][c:2]1[s:18][c:5]([CH2:6][C@@H:7]2[CH2:11][C@H:10]([c:12]3[s:17][c:15]([NH:16]C(Cc4ncccc4)=[O:19])[n:14][n:13]3)[CH2:9][CH2:8]2)[n:4][n:3]1)[CH2:22][c:23]5[n:28][cH:27][cH:26][cH:25][cH:24]5

참가 물질

7

반응물 2

HCID 853182-Pyridineacetic acidHCID 1184842105-[[(1S,3R)-3-(5-amino-1,3,4-thiadiazol-2-yl)cyclopentyl]methyl]-1,3,4-thiadiazol-2-amine

생성물 1

HCID 1184841812-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide

시약·촉매·용매 4

HCID 111923Propylphosphonic anhydride시약HCID 448383(3R,4R,5R,6R)-5-acetamido-2-[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-fluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid시약HCID 6228Dimethylformamide용매HCID 117669-Phenylanthracene내부 표준

반응 조건

온도
25 °C

출처 및 근거

ORD 기록
ord-d61b52a1025341d5ad0dc656521b43c5
출처 데이터셋
39k HTE dataset from Pfizer
원본 링크
출처 보기

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