Benzene, 1-ethoxy-2-iodo- → tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

HRID 2004416

반응식

HRID 2004416 반응식
[CH3:1][CH2:2][O:3][c:4]1[c:9](I)[cH:8][cH:7][cH:6][cH:5]1.[CH3:10][C:11]([O:14][C:15]([N:17]1[CH2:23][C@H:21]([OH:22])[CH2:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])[CH3:12]>>[CH3:1][CH2:2][O:3][c:4]1[c:9]([O:22][C@H:21]2[CH2:23][N:17]([C:15]([O:14][C:11]([CH3:13])([CH3:12])[CH3:10])=[O:16])[CH2:18][CH2:19][CH2:20]2)[cH:8][cH:7][cH:6][cH:5]1

참가 물질

8

반응물 2

HCID 136415Benzene, 1-ethoxy-2-iodo-HCID 1514398(R)-1-Boc-3-hydroxypiperidine

생성물 1

HCID 131737068tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

시약·촉매·용매 5

HCID 23683543Potassium t-amylate시약HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 15345279Dinitrato(1,10-phenanthroline)copper(II)촉매HCID 1140Toluene용매HCID 117669-Phenylanthracene내부 표준

반응 조건

온도
100 °C

출처 및 근거

ORD 기록
ord-eef729c0c9a24b8c8f4463d26e9a51c1
출처 데이터셋
39k HTE dataset from Pfizer
원본 링크
출처 보기

연결된 노트

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