Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium cyanoborohydride → 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone | HCID 11446818 | — |
| 촉매 | zinc(II)iodide | HCID 9883512 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol | HCID 11286977 | — |
반응 단계
To a solution of 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethanone (5.0 g, 26 mmol) in dichloroethane was added zinc iodide (2.7 ml, 39 mmol) followed by sodium cyanoborohydride (10 ml, 197 mmol). The reaction was stirred at RT for 18 h. Both TLC and LCMS showed one product was formed. MS+=175 (desired mass 192—OH). The mixture was filtered through celite and rinsed with dichloromethane. The filtrate was concentrated and dried in vacuum to afford the title compound as colorless oil. MS m/z: 175(M−H2O).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745484B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-ee744732b1db40f2af28ba7e8613f7fa |
| 출처 메모 | uspto-grants-2010_06 |