2-Amino-6-methoxy-3-nitropyridine → 2,3-Diamino-6-methoxypyridine

HRID 20088

반응식

HRID 20088 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1>CO.C(O)C>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1

참가 물질

3

반응물 1

HCID 38524282-Amino-6-methoxy-3-nitropyridine

생성물 1

HCID 30239202,3-Diamino-6-methoxypyridine

시약·촉매·용매 1

HCID 18681192Ethanol, mixt. with methanol용매

실험 절차

2-Amino-6-methoxy-3-nitropyridine (2.8 g, 16.5 mmol) was dissolved in warm 1:1 methanol/ethanol (200 mL). The solution was cooled, purged with argon, and 10% palladium on carbon was added (0.45 g). Hydrogen was introduced (1 atm) and the reaction stirred until complete. The catalyst was filtered and the solvent evaporated from the filtrate to give the title compound. MS 140 (M+1) 1H NMR (500 MHz, CDCl3) δ 6.93 (d, J=8 Hz, 1H), 6.04 (d, J=8 Hz, 1H), 4.15 (br s, 2H), 3.80 (s, 3H), 3.0 (br s, 2H).

후처리

  1. temperatureThe solution was cooled
  2. custompurged with argon, and 10% palladium on carbon
  3. additionwas added (0.45 g)
  4. additionHydrogen was introduced (1 atm)
  5. filtrationThe catalyst was filtered
  6. customthe solvent evaporated from the filtrate

출처 및 근거

ORD 기록
ord-393a1293af5f45da8e86eb6e83af40c9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745427B2

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