참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 7-Benzyl-3-methylxanthine | HCID 685630 | — |
| 반응물 | Diethyl(4-chlorobutyl)phosphonate | HCID 19689195 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate | HCID 22446297 | — |
반응 단계
20.4 g (0.08 mol) of 7-benzyl-3-methylxanthine were suspended in 200 ml of dimethylformamide (DMF), treated with 22 g (0.96 mol) of diethyl 4-chlorobutanephosphonate and 13.8 g (0.1 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05728686 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-7a6debe642dd4a55a17f79ac83e9ef86 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
