Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenyl formate → 5-((1H-Pyrrol-2-YL)methyl)-1H-pyrrole-2-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenyl formate | HCID 74626 | — |
| 반응물 | Dipyrromethane | HCID 140814 | — |
| 반응물 | HCID 178425415 | HCID 178425415 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Chlorin | HCID 65106 | — |
| 생성물 | 5-((1H-Pyrrol-2-YL)methyl)-1H-pyrrole-2-carbaldehyde | HCID 16732691 | — |
반응 단계
As part of our work in chlorin chemistry, we recently developed an efficient route for the synthesis of 1-formyldipyrromethanes.21 The formylation method entailed traditional Vilsmeier formylation or treatment of a solution of dipyrromethane in THF at room temperature with 2 molar equiv of MesMgBr and then at −78° C. with 2 molar equiv of phenyl formate. The subsequent workup and column chromatography afforded the desired 1-formyldipyrromethane in good yields.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745618B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-35956ce954c5456b92764c181b22ce1c |
| 출처 메모 | uspto-grants-2010_06 |