Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one | HCID 4293995 | — |
| 반응물 | (R)-1-Benzoyl-3-methylpiperazine | HCID 7578227 | — |
| 반응물 | Alfa-oxo-1H-pyrrolo-[2,3B]pyridine-3-acetic acid monopotassium salt | HCID 23721194 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)- | HCID 5495793 | — |
반응 단계
Potassium 7-azaindole 3-glyoxylate 3a (25.4 g, 0.111 mol), (R)-3-methyl-N-benzoylpiperazine 4a (22.7 g, 0.111 mol), 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) (33.3 g, 0.111 mol) and Hunig's Base (28.6 g, 0.222 mol) were combined in 500 ml of DMF. The mixture was stirred at room temperature for 8 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745625B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-78962d1c87974178b9fcd76dfc17aea7 |
| 출처 메모 | uspto-grants-2010_06 |