Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Benzyl 4-((3-methoxy-3-oxopropyl)amino)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Benzyl 4-oxopiperidine-1-carboxylate | HCID 643496 | — |
| 반응물 | Methyl 3-aminopropanoate hydrochloride | HCID 2734767 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | Benzyl 4-((3-methoxy-3-oxopropyl)amino)piperidine-1-carboxylate | HCID 68419530 | 87.4% |
반응 단계
A solution of benzyl 4-oxopiperidin-1-carboxylate (10 g), β-alanine methyl ester monohydrochloride (5.99 g), acetic acid (4 mL) and sodium triacetoxyborohydride (10.9 g) in dichloroethane (400 mL) was stirred overnight. The reaction mixture was washed with aqueous saturated sodium bicarbonate solution and saturated saline solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound (12.0 g, 87%) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745623B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-de45e883b33e49fb877442f2ee862f0f |
| 출처 메모 | uspto-grants-2010_06 |