Dimethylformamide → 2-(3-Methylisoxazol-5-yl)acetyl chloride

HRID 20269

반응식

HRID 20269 반응식
CN(C)C=O.[C:6](Cl)(=O)[C:7]([Cl:9])=[O:8].[CH3:12][C:13]1[CH:17]=[C:16](CC(O)=O)[O:15][N:14]=1>ClCCl>[CH3:12][C:13]1[CH:17]=[C:16]([CH2:6][C:7]([Cl:9])=[O:8])[O:15][N:14]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 41955322-(3-Methyl-1,2-oxazol-5-yl)acetic acid

생성물 1

HCID 123668732-(3-Methylisoxazol-5-yl)acetyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N,N-Dimethylformamide (few drops), followed by oxalyl chloride (9.5 mL, 106 mmol) were added dropwise to a cooled (10° C.) solution of (3-methyl-isoxazol-5-yl)-acetic acid (5 g, 35.4 mmol) in dichloromethane (50 mL), and the solution was allowed to warm to room temperature. The reaction was stirred for a further 3 hours, then concentrated under reduced pressure. The residue was azeotroped with toluene to afford the title compound.

후처리

  1. additionwere added dropwise to
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was azeotroped with toluene

출처 및 근거

ORD 기록
ord-35d1a0ec58494321a176c65bca0fac57
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745630B2

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