Diethyl (3-bromopropyl)phosphonate → Diethyl [3-(7-ethyl-3-methylxanthin-1-yl)propyl]phosphonate

반응식

[CH2:1]([N:3]1[C:11]2[C:10](=[O:12])[NH:9][C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:5]=[CH:4]1)[CH3:2].Br[CH2:16][CH2:17][CH2:18][P:19]([O:24][CH2:25][CH3:26])(=[O:23])[O:20][CH2:21][CH3:22]>>[CH2:1]([N:3]1[C:11]2[C:10](=[O:12])[N:9]([CH2:16][CH2:17][CH2:18][P:19](=[O:23])([O:24][CH2:25][CH3:26])[O:20][CH2:21][CH3:22])[C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:5]=[CH:4]1)[CH3:2]

참가 물질

반응물 2

HCID 283500Diethyl (3-bromopropyl)phosphonate

HCID 3507197-Ethyl-3-methyl-1,3,7-trihydropurine-2,6-dione

생성물 1

HCID 22446318Diethyl [3-(7-ethyl-3-methylxanthin-1-yl)propyl]phosphonate

실험 절차

The title substance was prepared from 0.041 mol of 7-ethyl-3-methyl-xanthine and 0.049 mol of diethyl 3-bromopropanephosphonate analogously to Example 32.

출처 및 근거

ORD 기록: ord-b873039c08354be38bd2be8966ce1a89
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05728686

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