4-Chlorophenyl isothiocyanate → tert-Butyl 4-{[(4-chlorophenyl)amino]carbonothioyl}-1,4-diazepane-1-carboxylate

HRID 20278

반응식

HRID 20278 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[C:11]([N:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:21]2[CH2:22][CH2:23][CH2:24][N:18]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:19][CH2:20]2)=[S:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 164804-Chlorophenyl isothiocyanateHCID 2756058Tert-butyl 1,4-diazepane-1-carboxylate

생성물 1

HCID 59347509tert-Butyl 4-{[(4-chlorophenyl)amino]carbonothioyl}-1,4-diazepane-1-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-chlorophenyl isothiocyanate (5.0 g, 29.95 mmol), and BOC-homopiperazine (6.0 g, 29.95 mmol) in ethanol (50 mL) was stirred at room temperature for 2 hours. The mixture was evaporated under reduced pressure, the residue was partitioned between ethyl acetate and water and the layers were separated. The organic phase was dried over MgSO4 and evaporated under reduced pressure to give the title compound as a white foam.

후처리

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue was partitioned between ethyl acetate and water
  3. customthe layers were separated
  4. dry with materialThe organic phase was dried over MgSO4
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-daa6eab60c9e4f4fa2b20aee2c27aaac
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745630B2

연결된 노트

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