참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Bromopropane | HCID 7840 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1H-Purine-2,6-dione, 3,7-dihydro-3-cyclopropyl- | HCID 3058996 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Cyclopropyl-7-propylxanthine | HCID 19689270 | — |
반응 단계
9.6 g (0.05 mol) of 3-cyclopropylxanthine were suspended in 150 ml of dimethylformamide and slowly deprotonated using 1.45 g (0.06 mol) of sodium hydride. When evolution of hydrogen was at an end, the solution was heated to 60° C. and treated dropwise with 6.77 g (0.055 mol) of bromopropane. After stirring at 70° C. for 3 hours, the solution was filtered, the dimethylformamide was evaporated under reduced pressure and the residue was crystallized from diisopropyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05728686 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-8e167d88150f459d95e6145c9ec1c182 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
